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KMID : 0978920110120040207
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Korean Journal of Clinical Geriatrics
2011 Volume.12 No. 4 p.207 ~ p.210
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Neuroleptic Malignant Syndrome in a Patient with Dementia with Lewy Bodies Receiving Donepezil - A Case Report -
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Na Ju-Young
Kim Meyung-Kug
Yoo Bong-Goo
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Abstract
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Neuroleptic malignant syndrome (NMS) refers to the combination of hyperthermia, extrapyramidal symptoms, altered consciousness and autonomic symptoms that can occur as a serious complication of the use of antipsychotic drugs. Donepezil-related NMS was rarely reported. We report a patient with dementia with Lewy bodies (DLB) who developed NMS following donepezil monotherapy. A 74-year-old female with DLB visited to our hospital with confusion, fever and severe muscle stiffness for 2 days. Four days before admission, she was started on donepezil to treat dementia. This report suggests that caution should be used when starting donepezil in patients DLB.
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KEYWORD
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Neuroleptic malignant syndrome, Lewy body disease, Donepezil
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